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  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
製品番号 製品名 CAS 番号 純度 構造式
  • HY-W006629
    (4S)​-4-Hydroxy-D-proline methyl ester hydrochloride 481704-21-6 98.0%
    (4S)-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (4S)-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    (4S)​-4-Hydroxy-D-proline methyl ester hydrochloride
  • HY-120397
    Bis-propargyl-PEG4 159428-42-9
    Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG4
  • HY-W004816
    Bis-Tos-PEG4 37860-51-8 99.50%
    Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-Tos-PEG4
  • HY-W067705
    3,6,9-Trioxaundecanedioic acid

    3,6,9-Trioxaundecanedioic Acid

    		13887-98-4 98.57%
    369-Trioxaundecanedioic Acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,6,9-Trioxaundecanedioic acid
  • HY-140898
    Biotin-PEG7-amine 1334172-76-7 98.0%
    Biotin-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG7-amine
  • HY-133390
    Azido-PEG1-azide 24345-74-2 99.11%
    Azido-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-azide
  • HY-133062
    Fmoc-NH-PEG5-CH2COOH 635287-26-2
    Fmoc-NH-PEG5-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG5-CH2COOH
  • HY-140023
    Propargyl-PEG4-CH2COOH 1429934-37-1
    Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-CH2COOH
  • HY-W040270
    Amino-PEG10-amine 928292-69-7
    Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.
    Amino-PEG10-amine
  • HY-W018291
    Mal-C6-amine TFA 731862-92-3 99.73%
    Mal-C6-amine (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-C6-amine TFA
  • HY-133272
    m-PEG5-SH 524030-00-0 98.0%
    m-PEG5-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG5-SH
  • HY-140431
    t-Boc-Aminooxy-PEG2-azide 252378-68-0
    t-Boc-Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. t-Boc-Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    t-Boc-Aminooxy-PEG2-azide
  • HY-153153
    Benzyl-PEG45-alcohol 26403-74-7 98.56%
    Benzyl-PEG45-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG45-alcohol
  • HY-133467
    Methyltetrazine-PEG5-methyltetrazine 98.52%
    Methyltetrazine-PEG5-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG5-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-PEG5-methyltetrazine
  • HY-138336
    Br-PEG3-MS 2702323-73-5
    Br-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG3-MS
  • HY-130525
    Iodo-PEG3-N3 936917-36-1
    Iodo-PEG3-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Iodo-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Iodo-PEG3-N3
  • HY-W013664
    Glycyl-l-serine 7361-43-5 99.71%
    Glycyl-l-serine is a PROTAC linker composed of glycine and serine. Glycyl-l-serine can be used in the synthesis of PROTACs, such as FPP29 (HY-P11228).
    Glycyl-l-serine
  • HY-141371
    Bromo-PEG2-CH2-Boc 1807518-63-3
    Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-CH2-Boc
  • HY-140974
    Mal-amido-PEG12-acid 2378428-27-2 99.32%
    Mal-amido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG12-acid
  • HY-140575
    N-Mal-N-bis(PEG4-NH-Boc) 2128735-27-1
    N-Mal-N-bis(PEG4-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Mal-N-bis(PEG4-NH-Boc)
PROTAC Linkers Isoform Comparison

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